On the functional consequences of epilepsy-causing mutations located in ion channels and the role of cytoplasmic protein regions in fast and slow inactivation of voltage-gated sodium channels [Elektronische Ressource] / Alexi Kirilov Alekov

Universität Ulm Abteilung Angewandte Physiologie Abteilungsleiter: Professor Lehmann-Horn ON THE FUNCTIONAL CONSEQUENCES OF EPILEPSY-CAUSING MUTATIONS LOCATED IN ION CHANNELS AND THE ROLE OF CYTOPLASMIC PROTEIN REGIONS IN FAST AND SLOW INACTIVATION OF VOLTAGE-GATED SODIUM CHANNELS Dissertation zur Erlangung des Doktorgrades der Humanbiologie der Medizinischen Fakultät der Universität Ulm vorgelegt von: Alexi Kirilov Alekov Dobrich, Bulgarien 2002 Amtierender Dekan: Prof. Dr. R. Marre 1. Berichterstatter: PD Dr. H. Lerche 2. Berichterstatter: Prof. Dr. O. Marti Tag der Promotion: 22.11.2002 Table of Contents TABLE OF CONTENTS 1. INTRODUCTION .........................................................................................................................1 1.1. Voltage-gated cation channels ..........................................................................................1 1.1.1. Voltage-gated sodium channels ......................................................................................4 1.1.1.1. Inactivation of the voltage-gated sodium channels ...................................................6 1.1.1.1.1. Fast inactivation ..................................................................................................6 1.1.1.1.2. Slow inac...............................