Novel mouse models for use in IL-17A and Th17 research [Elektronische Ressource] / Andrew Lewis Croxford

Novel Mouse Models for Use in IL-17A and Th17 Research Dissertation Zur Erlangung des Grades Doktor der Naturwissenschaft Am Fachbereich Biologie Der Johannes Gutenberg-Universität Mainz Andrew Lewis Croxford Geb. am 1. Januar 1981 in New York, USA Mainz, 2009 ABBREVIATIONS.......................................................................................................................8 1 INTRODUCTION..............11 1.1 EAE, AN ANIMAL MODEL FOR MS.....................................................................................11 1.2 THE T HELPER CELL SUBSET PARADIGM............12 1.3 DIFFERENTIATION OF TH17 CELLS12 1.4 TRANSCRIPTIONAL CONTROL OF TH17 CELLS ...................................................................13 1.5 FOXP3 AND RORγT............................................14 1.6 IL-23 ..................................15 1.7 IL-17A...............................................................17 1.8 IL-17F................................................................17 1.9 IL-17A SIGNALING AND TISSUE INFLAMMATION.............................18 1.10 IL-17A AND AUTOIMMUNITY...........................19 1.11 G-PROTEIN SIGNALLING AND AUTOIMMUNITY...............................20 1.12 AIM OF THIS THESIS..........................................................................................................22 2 MATERIALS AND METHODS ...............................