Novel Cu(II)-mediated methodologies for PET-induced cyclizations, including asymmetric induction, and a biomimetic approach to the basic taxane sceleton [Elektronische Ressource] / by Yevgeny Makhynya

Novel Cu(II)-mediated Methodologies for PET-induced Cyclizations, including Asymmetric Induction, and a Biomimetic Approach to the Basic Taxane Skeleton DISSERTATION submitted to the Universit t Duisburg-Essen Standort Essen Fachbereich Chemie in fulfilment of the Dr. rer. nat. degree by Yevgeny Makhynya from Kiev, Ukraine M lheim an der Ruhr Germany 2004 Tag der mndlichen P? r fung: 21.01.2005 Pr fungsvorsitzender: Prof. Dr. R. Boese 1. Gutachter: Prof. Dr. M. Demuth 2. Gutachter: Prof. Dr. R. Sustmann This work was conducted at the Max-Planck-Institut f r Bioanorganische Chemie (former Max-Planck-Institut f r Strahlenchemie ), M lheim an der Ruhr , between August 2001 and November 2004 under the direction of Prof. M. Demuth. My sincerest thanks goes to Prof. M. Demuth for his constant help and advises in research, for his kind help in giving the possibility to perform the practical part of my diploma thesis and for his valuable help and support at all stages of my Ph.D. studies. I am very grateful to the State of North-Rhine Westfalia, Ministry for Education and Research, for partial support of the present Ph.D. work. The kind support of this work at the Max-Planck-Institut f r Bioanorganische Chemie by Prof. W. Lubitz and K. Wieghard are gratefully acknowledged. I thank Prof. W.