Novel Benzindoloazecines and Dibenzazecines [Elektronische Ressource] : Synthesis and Affinities for the Dopamine Receptors / Dina Robaa. Gutachter: Jochen Lehmann ; Gerhard Scriba ; Peter Gmeiner

Novel Benzindoloazecines and Dibenzazecines - Synthesis and Affinities for the Dopamine Receptors Dissertation zur Erlangen des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) Vorgelegt dem Rat der Biologisch-Pharmazeutischen Fakultät der Friedrich-Schiller-Universität Jena von Dina Robaa geboren am 17. Oktober 1978 in Alexandria 1. Gutachter: Prof. Dr. Jochen Lehmann, Jena 2. Gutachter: Prof. Dr. Gerhard Scriba, Jena 3. Gutachter: Prof. Dr. Peter Gmeiner, Erlangen Tag der öffentlichen Verteidigung: 5. Mai 2011 I Table of contents 1. Introduction ................................................................................................................... 1 1.1. Receptor structure ....................................................................................................... 3 1.2. Tissue distribution ............... 4 1.3. Signal transduction ............................................................... 6 1.4. Functions of the dopamine receptors and their therapeutic implications ............... 7 1.4.1. Control of locomotion and application in movement disorders ..................................... 7 1.4.2. Role in reward and reward-seeking behavior and clinical implication in drug abuse and addictive disorders ............................................................................. 8 1.4.3. Role in psychosis and schizophrenia ......... ...........