NMR spectroscopic investigations reveal insights into antibody secretion, amyloidogenic folding intermediates, and the process of focal adhesion [Elektronische Ressource] / Sandra Groscurth

NMR spectroscopic investigations revealinsights into antibody secretion,amyloidogenic folding intermediates,and the process of focal adhesionSandra GroscurthDissertation 2009¨ ¨TECHNISCHE UNIVERSITAT MUNCHEN¨ ¨TECHNISCHE UNIVERSITAT MUNCHENDepartment ChemieLehrstuhl IIfu¨r Organische ChemieNMR spectroscopic investigations revealinsights into antibody secretion,amyloidogenic folding intermediates,and the process of focal adhesionSandra GroscurthVollst¨andiger Abdruck der von der Fakult¨at fu¨r Chemie der Technischen Universit¨atMu¨nchen zur Erlangung des akademischen Grades einesDoktors der Naturwissenschaftengenehmigten Dissertation.Vorsitzender: Univ.-Prof. Dr. M. SattlerPru¨fer der Dissertation: 1. Univ.-Prof. Dr. H. Kessler2. Univ.-Prof. Dr. Th. Kiefhaber3. Univ.-Prof. Dr. J. BuchnerDie Dissertation wurde am 21.01.2009 bei der Technischen Universit¨at Mu¨ncheneingereicht und durch die Fakult¨at fu¨r Chemie am 03.03.2009 angenommen.Those who are not shockedwhen they first come acrossquantum mechanics cannotpossibly have understood it(Niels Henrik David Bohr)AcknowledgementThe work presented in this thesis was prepared from May 2005 until October 2008 inthe group of Prof. Dr. Horst Kessler at the Department of Chemistry of the TechnicalUniversity of Munich, Germany.I would like to thank my supervisor Prof. Dr.