Nitric oxide-cGMP signal transduction in the injury, matrix expansion and progression of anti-thy1-induced renal disease of the rat [Elektronische Ressource] / von Yingrui Wang

Aus der Klinik für Innere Medizin mit Schwerpunkt Nephrologie der Medizinischen Fakultät der Charité – Universitätsmedizin Berlin DISSERTATION Nitric oxide-cGMP signal transduction in the injury, matrix expansion and progression of anti-thy1-induced renal disease of the rat Zur Erlangung des akademischen Grades Doctor medicinae (Dr. med.) vorgelegt der Medizinischen Fakultät der Charité - Universitätsmedizin Berlin von Yingrui Wang aus Guangdong, V.R. China Dekan: Prof. Dr. med. Martin Paul Gutachter: 1. Prof. Dr. med. Frank Strutz 2. PD. Dr. med. Ulrich Wenzel 3. PD. Dr. med. Harm Peters Datum der Promotion: 14 März 2005 Contents 1 Introduction 1 1.1 Pathogenesis and therapy of chronic progressive renal disease 2 1.1.1 Histological and molecular characteristics 2 1.1.2 The central role of TGF-beta in renal fibrosis 2 1.1.3 The sequence of phases leading to progressive renal fibrosis 3 1.1.4 Therapeutic approaches to chronic progressive renal disease 4 1.2 The L-arginine-NO pathway in renal disease 5 1.2.1 Two faces of the L-arginine-NO pathway 5 1.2.2 NO synthases 6 1.2.3 Effects of L-arginine supplementation on renal disease 7 1.3 NO-cGMP signaling in renal disease 7 1.3.