New insights into the stratum corneum lipid membrane organisation [Elektronische Ressource] : an X-ray and neutron scattering study / von Jarmila Zbytovská

NEW INSIGHTS INTO THE STRATUM CORNEUM LIPID MEMBRANE ORGANISATION AN X-RAY AND NEUTRON SCATTERING STUDY Dissertation zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) vorgelegt der Mathematisch-Naturwissenschaftlich-Technischen Fakultät (mathematisch-naturwissenschaftlicher Bereich) der Martin-Luther-Universität Halle-Wittenberg von Frau Mgr. Jarmila Zbytovská geboren am 17. 9. 1976 in Prag (Tschechische Republik) Gutachter: 1. Prof. Dr. Dr. Reinhard Neubert 2. Prof. Dr. Siegfried Wartewig 3. Doc. RNDr. Pavel Doležal CSc. Halle (Saale), den 20. 10. 2006 urn:nbn:de:gbv:3-000012474[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000012474]CONTENTS CONTENTS LIST OF ABBREVIATIONS IVLIST OF SYMBOLS V1 INTRODUCTION 12 CURRENT KNOWLEDGE STATUS OF THE STRATUM CORNEUM STRUCTURE AND TRANSDERMAL PERMEATION ENHANCEMENT 42.1 The organization of the mammalian skin 42.2 The stratum corneum 52.2.1 TheoriginoftheSClipids 52.2.2 ThelipidcompositionwithintheSC 62.2.3 TheorganizationoftheSClipidmatrix 82.3 Drug penetration routes through the skin 102.4 Modes of actions of permeation enhancers 103 BASIC PRINCIPLES OF EXPERIMENTAL TECHNIQUES EMPLOYED 123.1 Differential scanning calorimetry 123.2 Infrared and Raman spectroscopy 133.2.1 Conformationallysensitivebandsofhydrocarbonchains 133.3 Scattering techniques 153.3.