Nef-mediated primate lentiviral immune evasion mechanisms [Elektronische Ressource] / presented by Anke Specht

University of Ulm Institute of Virology Director: Prof. Dr. Thomas Mertens Nef-mediated primate lentiviral immune evasion mechanisms Dissertation to obtain the Doctoral Degree of Human Biology (Dr. biol. hum.) at the Faculty of Medicine, University of Ulm. presented by Anke Specht Koblenz 2008 Present Dean: Prof. Dr. Klaus-Michael Debatin 1. Reviewer: Prof. Dr. Frank Kirchhoff 2. Reviewer: Prof. Dr. Steffen Stenger Graduation Day: 17.02.2009INDEX I Index List of Abbreviations ..........................................................................................III 1. Introduction.....................................................................................................1 1.1 Discovery, origin and genomic organization of HIV ...................................1 1.2 Nef: a multifunctional viral persistence factor ............................................3 1.3 A HLA-C SNP is associated with improved control of HIV-1......................7 1.4 Scientific aims............................................................................................8 2. Materials and Methods ...................................................................................9 2.1 Materials ....................................................................................................9 2.1.1 Bacteria................................................................................................9 2.1.