Muscarinic receptors mediated stimulation and intracellular signaling pathways involved in human lung fibroblast proliferation [Elektronische Ressource] / vorgelegt von Amit Bahulayan

Muscarinic Receptors Mediated Stimulation and Intracellular Signaling Pathways Involved in Human Lung Fibroblast Proliferation Dissertation zur Erlangung des Doktorgrades (Dr. rer. nat) der Mathemathisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn vorgelegt von Amit Bahulayan aus Mumbai 2009 Angefertigt mit der Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn 1. Referent: Prof. Dr. med. Kurt Racké 2. Referent: Prof. Dr. med. Klaus Mohr Tag der Promotion: 13.05.2009 Dedicated to my parents for their support all these years Table of Contents Abbreviations 1 Introduction 1 1.1 Neuronal and Non Neuronal Acetylcholine 2 1.2 Cholinoceptors 3 1.2.1 Nicotinic Receptors 3 1.2.2 Muscarinic Receptors 4 1.3 Molecular and Pharmacological Classification of Muscarinic Receptor Subtypes 5 1.3.1 Molecular Biology of Muscarinic Receptors 5 1.3.2 Pharmacological Classification of Muscarinic Receptor Subtypes 6 1.4 Muscarinic Coupling to G-proteins and Effector Molecules 8 1.4.1 Adenylyl Cyclase 10 1.4.2 Phospholipase C 11 1.5 Mitogen Activated Protein Kinases 12 1.5.1 MAPKs in Regulation of Cell Cycle 14 1.