Murine model system for EBV-related diseases [Elektronische Ressource] / submitted by Magdalena Zychlinska

Thesis for the Degree of Doctor of Natural Sciencesat the Faculty of Biology,Ludwig-Maximilians-Universitaet MuenchenMurine Model System forEBV-related Diseasessubmitted byMagdalena Zychlinska,from Gdansk, PolandMunich, 2007STATEMENTI declare that this is my first dissertation work to pursue the PhD degree.I have written this thesis independently, without help of the others. The content of thisthesis is based on experiments I performed myself.Magdalena ZychlinskaGermany, Munich, 06.02.2007First examiner: Prof. Dr. Dirk EickSecond examiner: Prof. Dr. Hans-Urlich KoopDate of the oral examination: 13.07.2007TABLE OF CONTENTSABBREVIATIONS ...................................................................................................... 11. INTRODUCTION .................................................................................................... 41.1. EPSTEIN-BARR VIRUS (EBV) – AN UNUSUAL HUMAN VIRUS .................................... 41.2. GENE EXPRESSION OF EBV................................................................................. 61.3. B CELLS AND THEIR DEVELOPMENT ....................................................................... 81.4. BIOLOGY OF EBV INFECTION IN VIVO .................................................................. 111.5. EBV-ASSOCIATED HUMAN DISEASES................................................................... 141.6. TRANSGENIC MURINE MODEL SYSTEMS...............................................