Multivariate statistical analysis of epigenetic regulation with application to the analysis of human embryonic stem cells [Elektronische Ressource] / Lukas W. Chavez Wurm

GMultivaereicriate(Dr.statisticalUnivanalysisderofFepigeneticInformatikregulationErlangungwitheinesapplicationhaftetonat)thehanalysisMathematikofFhumanBerlinembdesryradesonicDoktorsstemNaturwissensccellsnLukrer.asamW.acChabvhezundWderurmreien2010ersit?tDissertationzurMolecularSupdisputation:ervisor:alterProf.VingronDr.Prof.MartinSaarlandes)VingronDr.(Max-Planck-Institutek-InstitutenforJ?rnMolecularersit?tGeofnProf.etics)MartinA(Max-Plancdvisor:forDr.GeRalfetics)HerwigDr.(Max-PlancWk-Institute(UnivfordesMolecularDateGenetics)theReview15.12.2010er:43Contents.1.Introvdu.c.t.iCpGo.n.53.3.51.162Humanorkem.bry.onic.stem.cells.(hES.Cs)......of...man.and.................er..........5eth1.2.T.ranscri56ptional.regulation.ofagepluri.pdepotency4.1.68...con...deriv..........................6441.3.DNA.meth.ylation3.3.2.......3.3.3.......3.3.4.......score.....of...57.ylated...w.......4.dermal.stem.core.trolling.tal.....4.39.1.4.In.troMeDIP-Seqductionprolesto.metho3.2.2dsanalysisand.limitations.for.d.etec.ti.ng40DNAhmenmeth.ylation...10.1.5.Aims.of.theNormalizationthesis................Reads.(rpm).............factors...............curv...............e12score2.Exp.erimental.techniques.16.2.1methDNA.arra.ys......Ev.data.......Iden.tially.(DMRs).....MEDIPS.pac...............and.during.of.ry.ells.tifying.net.OCT4.otency.Exp.ced.metho..16.2.2.Statistical.testingqualitometricsf.dieren.tial.expression....4.4.W.meth...77...33.Co.erage..............19.2.3.Second.generation.sequen.c.i.ng3.2.