Multi-directional diffusion weighted imaging [Elektronische Ressource] : implementation, verification and clinical application / vorgelegt von Kamil Marek Gorczewski

Aus der Radiologischen Universitätsklinik TübingenAbteilung für Diagnostische und Interventionelle NeuroradiologieÄrztliche Direktorin: Professor Dr. U. ErnemannMulti-directional diffusion weighted imaging:Implementation, verification and clinical applicationInaugural-Dissertationzur Erlangung des Doktorgradesder Humanwissenschaftender Medizinischen Fakultätder Eberhard Karls Universitätzu Tübingenvorgelegt vonKamil Marek GorczewskiausGliwice, Polen2011Dekan: Professor Dr. I. B. Autenrieth1. Berichterstatter: Professor Dr. U. Klose2. Berichterstatter: Professor Dr. D. KernMulti-directional difiusion weighted imaging: Implementation, veri-flcation and clinical applicationKamil GorczewskiAbstractAwaterdifiusioninahumanbraincanbeusedtoanalyzeflberswithinthewhitematter.The basis of the method is a measurement of a MR signal attenuation due to the waterparticles motion in a presence of a magnetic fleld gradient. The signal loss is related tothe free path that a particle can travel. The obstacles keep the signal from the waterspins coherent. Therefore, the attenuation of MR signal is stronger in the directions ofthe axons.The information about the directional structure of the white matter can be extractedfrom the data with various methods. Those approaches can be divided into two groups:a model-based and direct measurements. Both groups have their own advantages anddisadvantages.