mTOR inhibition impairs proliferation of hepatocytes with DNA damage during chronic liver injury thereby delaying liver tumor development [Elektronische Ressource] / Laura Elisa Buitrago Molina

mTOR Inhibition Impairs Proliferation of Hepatocytes with DNA Damage during Chronic Liver Injury thereby Delaying Liver Tumor Development Der Naturwissenschaftlichen Fakultät der Gottfried Wilhelm Leibniz Universität Hannover zur Erlangung des Grades DOKTORIN DER NATURWISSENSCHAFTEN Dr. rer. nat. genehmigte Dissertation von Master of Science Laura Elisa Buitrago Molina geboren am 07.07.1978 in Palmira, Valle, Kolumbien Hannover 2010 Referee: Prof. Dr. med. Nisar Malek Co-referee: PD Dr. med. Arndt Vogel Tag der Promotion: 28. Mai 2010 The following study has been carried out under the supervision of Dr. med. Arndt Vogel Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany, between August 2005 and December 2009. Declaration: Here with I declare that the study has been done by my own under the guidance of Priv.-Doz. Dr. med. Arndt Vogel and all the information provided is novel and true and has not been submitted to any other Institute or University to ob-tain any other degree. Laura Elisa Buitrago Molina Acknowledgements I am very grateful to Prof. Dr. M.P. Manns, Chairman of the Department of Gastro-enterology, Hepatology and Endocrinology, for giving me the opportunity to pursue my research in Hannover Medical School.