Mps1-dependent phosphorylation of the kinetochore protein Ndc80 is an intrinsic step in spindle checkpoint activation [Elektronische Ressource] / presented by Stefan Kemmler

Mps1-dependent phosphorylation ofthe kinetochore protein Ndc80 is an intrinsic step inspindle checkpoint activationDissertationsubmitted to theCombined Faculties for the Natural Sciences and for Mathematicsof the Ruperto-Carola University of Heidelberg, Germanyfor the degree ofDoctor of Natural Sciencespresented byStefan KemmlerDissertationsubmitted to theCombined Faculties for the Natural Sciences and for Mathematicsof the Ruperto-Carola University of Heidelberg, Germanyfor the degree ofDoctor of Natural Sciencespresented byDiplom-Biologist Stefan Kemmlerborn in: KarlsruheOral-examination: 17.12.2007Mps1-dependent phosphorylation ofthe kinetochore protein Ndc80 is an intrinsic step inspindle checkpoint activationReferees: Prof. Dr. Michael Brunner PD Dr. Johannes LechnerDiese Arbeit ist meinen Eltern gewidmet.TABLE OF CONTENTSTable of contens I-IVAbbreviations V-VISummary 00 1Zusammenfassung 00 31 Introduction 00 51.1 S. cerevisiae as a model organism 00 51.2 The cell cycle 00 51.3 Mitotic checkpoints 00 81.3.1 The spindle assembly checkpoint (Mad2-checkpoint) 0091.3.1.1 Microtubule-Attachment 0091.3.1.2 Kinetochore-Tension 0121.3.