Monocyte chemoattractant protein-1 (MCP-1) transgenic mice [Elektronische Ressource] : lessons from cardioprotection against ischemia to autoimmune inflammatory diseases / vorgelegt von Alessandra Martire

Monocyte chemoattractant protein-1 (MCP-1)transgenic mice: lessons from cardioprotectionagainst ischemia to autoimmune inflammatorydiseasesInaugural-Dissertationzur Erlangung des Grades eines Doktors der Biologiedes Fachbereichs Humanmedizinder Justus-Liebig-Universität GiessenVorgelegt von Alessandra Martireaus Rom, ItalienGiessen 2002Aus dem Max-Planck-Institutfür Physiologische und Klinische ForschungKerckhoff-InstitutAbteilung Experimentelle KardiologieLeiter: Prof. Dr. W. Schaperin Bad NauheimGutachterin: Prof. Dr. W. Schaper Prof. Dr. E. Baumgart-VogtTag der Disputation: 01.12.2003for who really loves me1. Introduction - 1 -1. Introduction1.1. MCP-1MCP-1 is a glycoprotein of 76 amino acids that was isolated and identified for thefirst time from human tumor cell lines as related factor with monocytechemotactic activity (Van Damme, Decock et al. 1989) (Fig. 1).It belongs to chemokines (chemotactic cytokines), a family of low-molecular-weight (8-10 kD) proteins with four conserved cysteins. Chemokines are dividedinto two subfamilies, called C-X-C and C-C chemokines, depending on whetherthe two cysteins nearest the N-terminals are separated by one amino acid or not(Miller and Krangel 1992; Baggiolino, Dewald et al. 1994). Recently, two otherssubfamilies have been identified: the C chemokines, which lack the first andthird of the conserved cysteine, and transmembrane chemokines with an activeC-X-3C motif. (Bazan, Bacon et al. 1997).