Monitoring of tolerance induction and maintenance in clinically relevant transplant models [Elektronische Ressource] / von Weihua Gong

Aus der Institut für Medizinische Immunologie der Medizinischen Fakultät Charité-Universitätsmedizin Berlin DISSERTATION Monitoring of tolerance induction and maintenance in clinically relevant transplant models Zur Erlangung des akademischen Grades Doctor medicinae (Dr. med.) vorgelegt der Medizinischen Fakultät Charité- Universitätsmedizin Berlin von Herrn Weihua Gong aus V.R. China Gutachter: 1. Professor Dr. rer. nat..Birgit Sawitzki........... 2. Professor Dr. rer. nat. Reinhard Schwinzer.. 3. Privatdozent. Dr. med..Andreas Pascher..... Datum der Promotion: …………19.11.2010……………….. ii TABLE OF CONTENTS 1. INTRODUCTION ................................................................................................ 1 1.1. Immune response to allogeneic transplants ................................................. 1 1.2. Novel treatment strategies in transplantation ................ 3 1.2.1. Effect of non-depleting anti-CD4 antibody (RIB5/2) on graft survival ...... 5 1.3. Clinical challenges for induction of allograft acceptance............................... 7 1.3.1. Impact of weight difference between donor and recipient on primary graft function ............................................................................................................. 8 1.3.2. Impact of heterologous immunity (cytomegalovirus infection) on graft function ........... 10 1.3.2.1.