Molecular modelling and simulation of retroviral proteins and nanobiocomposites [Elektronische Ressource] / vorgelegt von Sergey Shityakov

Molecular modelling and simulation of retroviral proteins and nanobiocomposites Dissertation zur Erlangung des naturwissenschaftlichen Doktorgrades der Julius-Maximilians-Universität Würzburg vorgelegt von Sergey Shityakov aus Novgorod the Great, Russland Würzburg 2011 2 3 Eingereicht am: Mitglieder der Promotionskommission: Vorsitzender: 1. Gutachter: Prof. Dr. Thomas Dandekar 2. Gutachter: Prof. Dr. Axel Rethwilm Tag des Promotionskolloquiums: Doktorurkunde ausgehändigt am: 4 List of contents List of tables...............................................................................................................................6 List of figures.............................................................................................................................6 General introduction.................................................................................................................11 Motivation for present research................................................................................................13 1 Structural and docking analysis of HIV-1 integrase and Transportin-SR2 interaction: Is this a more general and specific route for retroviral nuclear import and its regulation?................16 1.1 Overview.................................