Molecular mechanisms of serotonergic signaling [Elektronische Ressource] : role in neuronal outgrowth and receptor oligomerization / vorgelegt von Fritz Kobe

Molecular Mechanisms of Serotonergic Signaling: Role in Neuronal Outgrowth and Receptor Oligomerization Dissertation zur Erlangung des mathematisch-naturwissenschaftlichen Doktorgrades "Doctor rerum naturalium" der Georg-August-Universität Göttingen vorgelegt von Fritz Kobe aus Dresden Göttingen 2010   II This thesis has been written independently and with no other aids and sources than quoted. Fritz Kobe Göttingen, March 2010   III Referent: Prof. Dr. Michael Hörner Koreferent: Prof. Dr. Erwin Neher Tag der mündlichen Prüfung: 30.04.2010   IVContents 1 INTRODUCTION.......................................................................................................1 1.1 G-Protein coupled receptors...................................................................................1 1.2 G-protein mediated signaling..................................................................................4 1.3 Post-translational modifications of the receptors....................................................6 1.4 Serotonin (5-Hydroxytryptamine) receptors............................................................7 1.5 Oligomerization of G-protein coupled receptors ...................................................12 1.6 Aims of the study ...............................................................................