Molecular mechanisms of parenchymal injury and the role of duct obstruction and ductal hypertension in the pathogenesis of chronic pancreatitis [Elektronische Ressource] / vorgelegt von Umeshkumar Bhanot

Universitätsklinikum Ulm Institut für Pathologie Direktor: Prof. Dr. med. P. Möller Molecular Mechanisms of Parenchymal Injury and the Role of Duct Obstruction and Ductal Hypertension in the Pathogenesis of Chronic Pancreatitis Dissertation zur Erlangung des Doktorgrades der Biomedizinischen Wissenschaften der Medizinischen Fakultät der Universität Ulm vorgelegt von Umeshkumar Bhanot, MD aus Pune, Indien ULM, 2009 Amtierender Dekan: Prof. Dr. Thomas Wirth 1. Berichterstatter: Prof. Dr. P. Möller 2. Berichterstatter: Prof. Dr. Dr. M. Bachem Tag der Promotion: 28.1.2011 - 2 - Table of contents List of Abbreviations………………………………………………………………....5 1. Introduction………………………………………………………........................7 1. 1 Definition of chronic pancreatitis(CP) ………………………………….. ….7 1. 2 Etiology of chronic pancreatitis……………………….…………………….. 7 1. 3 Theories of chronic pancreatitis pathogenesis………………………........ 8 1. 4 New developments…………………………………………………………... 9 1. 5 Pancreatic stellate cells………..……………………………………………. 11 1. 6 Cellular immune response in chronic pancreatitis……………………….. 11 1. 7 Morphology of chronic pancreatitis…………………………………………12 2. Parenchymal Regression in Chronic Pancreatitis Spares Islets Reprogrammed for Expression of NF B and IAPs………………………… 13 2. 1 Introduction and background……………………………………………….. 13 2.