Molecular mechanisms of classical fear conditioning: [Elektronische Ressource] : GABAergic factors and their role in fear-related network activities / von: Jorge R. Bergado Acosta

MOLECULAR MECHANISMS OF CLASSICAL FEAR CONDITIONING: GABAEERRGGIICC FFAACCTTOORRSS AANNDD TTHHEEIIRR RROOLLEE IINN GABA FEAR-RELATED NETWORK ACTIVITIES. Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium genehmigt durch die Fakultät für Naturwissenschaften der Otto-von-Guericke-Universität Magdeburg von: Dipl. biol. Jorge R. Bergado Acosta geb. am: 24.07.1976 in: Matanzas, Kuba Gutachter: Prof. Dr. Oliver Stork Prof. Dr. Gal Richter-Levin Eingereicht am: 20.07.2009 Verteidigt am: 25.05.2010 Index. Zusammenfassung………………………………………………………………………… 5 Summary…………………………………………………………………….……………… 6 1. Introduction…………………………………………………………………………… 8 1.2. Fear memory 8 1.2.1. Classical fear conditioning…………………………………………………… 8 1.2.2. Brain areas involved in fear conditioning………………………………… 10 1.2.3. Plasticity of local circuits in the amygdala during fear conditioning……………………………………………… 15 1.3. GABA interneurons………………………………………………………………… 19 1.3.1. GABA synthesis, receptors and reuptake…………………………………… 19 1.3.2. GABA interneurons are critical in fear memory…………………………… 20 1.4. Network activities involved in fear conditioning……………………………… 23 1.4.1. Oscillatory network activities and GABA………………………………… 23 1.4.2. Role of theta in behavior and memory in general………………………… 25 1.4.3.