Molecular interaction of the human metalloprotease meprin beta with the amyloid precursor protein, ADAM10, and ADAM17 based on proteomics [Elektronische Ressource] / Tamara Jefferson

Molecular interaction of the human metalloprotease meprin beta with the amyloid precursor protein, ADAM10, and ADAM17 based on proteomics Dissertation Zur Erlangung des Grades „Doktor der Naturwissenschaften” Am Fachbereich Biologie Der Johannes Gutenberg-Universität Mainz vorgelegt von Tamara Jefferson geboren am 07.10.1981 in Wiesbaden Mainz, November 2011 Dekan: Erster Gutachter: Zweiter Gutachter: Tag der mündlichen Prüfung: 08.12.2011 Preface This PhD thesis has been prepared partly cumulative. The data obtained in the presented work has been described in detail in one publication and three manuscripts which are attached as appendix 1, 2, 3, and 4. 1. Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo. Jefferson T*, Čaušević M*, Auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond JS, Overall CM, Pietrzik CU, Becker-Pauly C. August 5, 2011 The Journal of Biological Chemistry, 286, 27741-27750. 2. The degradome of the metalloproteases meprin α and β at a glance: TAILS degradomic analysis reveals substrates, inhibitors, and a proteolytic cascade between meprin β and ADAM10.