Molecular characterization of the immune modulatory function of matrix metalloproteinase-7, a factor in the tumour micromilieu [Elektronische Ressource] / Vijay Alla

Molecular Characterization of the Immune Modulatory Function of Matrix Metalloproteinase-7, a Factor in the Tumour Micromilieu Dissertation Zur Erlangung des Grades Doktor der Naturwissenschaften Am Fachbereich Biologie der Johannes Gutenberg-Universität Mainz Vijay Alla geb. am 28. August 1978 in Indien Mainz, June 2007 Table of Contents Table of Contents 1 Introduction................................................................................................................ 1 1.1 Tumourigenesis .................................................................................................. 1 1.2 Apoptosis............................................................................................................ 1 1.2.1 Signalling pathways of apoptosis ........................................................... 2 1.2.1.1 Death receptor mediated pathway............................................ 2 1.2.1.2 Mitochondrial pathway ............................................................ 4 1.2.1.3 Other pathways......................................................................... 5 1.2.2 Regulation of apoptosis .......................................................................... 6 1.2.2.1 CD95 and CD95 ligand 6 1.2.2.2 Caspase activity........................................................................ 7 1.2.2.3 Bcl-2 protein family ..........................................................