Molecular basis of translocation, {α-amanitin [alpha-amanitin] inhibition, and CPD damage recognition by RNA polymerase II [Elektronische Ressource] / Florian Brückner

Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie der Ludwig-Maximilians-Universität München Molecular basis of translocation, -amanitin inhibition, and CPD damage recognition by RNA polymerase II Florian Brückner aus München 2008 Erklärung II Erklärung Diese Dissertation wurde im Sinne von §13 Abs. 3 der Promotionsordnung vom 29. Januar 1998 von Herrn Prof. Dr. Patrick Cramer betreut. Ehrenwörtliche Versicherung Diese Dissertation wurde selbständig und ohne unerlaubte Hilfe erarbeitet. München, am 22. April 2008 Florian Brückner Dissertation eingereicht am 22. April 2008 1. Gutachter: Prof. Dr. Patrick Cramer 2. Gutachter: Prof. Dr. Karl-Peter Hopfner Mündliche Prüfung am 21. Mai 2008 Acknowledgements III Acknowledgements This work was accomplished in the laboratory and under supervision of Patrick Cramer at the Gene Center in Munich. It was a very exciting and enjoyable experience for me to be in-volved in highly interesting basic research at this excellent place. I am deeply grateful to Patrick for this opportunity and for his continuous personal support. His excitement about science, cheerful character and his encouraging and respectful attitude towards his cowork-ers are infectious and create an extremely pleasant and motivating atmosphere in the lab. All this was crucial for keeping my motivation high and turning my efforts into success.