Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation [Elektronische Ressource] / by Yijian Rao

Molecular basis for SH3 domain regulation of F-BAR-mediated membrane deformation Inaugural-Dissertation to obtain the academic degree Doctor rerum naturalium (Dr. rer. nat.) submitted to the Department of Biology, Chemistry and Pharmacy of Freie Universität Berlin By Yijian Rao From Fujian, China November, 2010 Die vorliegende Arbeit wurde in der Zeit von März 2007 bis November 2010 unter Anleitung von Prof. Dr. Volker Haucke am Institut für Chemie-Biochemie der Freien Universität Berlin im Fachbereich Biologie, Chemie, Pharmazie durchgeführt. st1 Reviewer: Prof. Dr. Volker Haucke nd2 Reviewer: Prof. Dr. Wolfram Saenger Date of defence: 13-01-2011 Acknowledgements I would like to thank all people who have helped and inspired me during my doctoral study. First and foremost, I would like to express my deep and sincere gratitude to my supervisor Prof. Dr. Volker Haucke. Thank you for giving me the opportunity to enter the world of biological science and perform my research in his lab. His contagious enthusiasm for science has motivated all people in his lab, including me. In addition, I am thankful for his understanding, encouraging and personal guidance. I would like to thank all former and current members of AG Haucke’s lab for my thesis support and for creating a homey place to work. Special thanks to Dr. Arndt Pechstein and Dr. Dmytro Puchkov for their contribution to my project.