Molecular analysis of the aureothin biosynthesis gene cluster from streptomyces thioluteus HKI-227 [Elektronische Ressource] : new insights into polyketide assemply / von Jing He

Molecular Analysis of the Aureothin Biosynthesis Gene Cluster from Streptomyces thioluteus HKI-227; New Insights into Polyketide Assembly Dissertation zur Erlangung des akademischen Grades doctor rerum naturalium vorgelegt dem Rat der Biologisch-Pharmazeutischen Fakultät der Friedrich-Schiller-Universität Jena von Jing He Geboren am 10.02.1977 in Wuhan, People’s Republic of China Jena, im November 2004 Gutachter 1. Prof. Dr. Susanne Grabley 2. Prof. Dr. Erika Kothe 3. Prof. Dr. Jörn Piel Tag der Doktorprüfung: 12 January 2005 Tag der öffentlichen Verteidigung: 31 January 2005 Index IIndex Abbreviation ..............................................................................................................................i A. Introduction .......................................................................................................1 1. Streptomycetes as Producers of Bioactive Secondary Metabolites .................... 1 2. Microbial Polyketide Biosynthesis..........................................................................3 2.1 Genetic Contributions to Understanding Polyketide Biosynthesis.................................3 2.2 Molecular Diversity of Polyketides......................................................................................5 2.3 Classification of Polyketide Synthases ..............................