Modulation of posttranscriptional and posttranslational regulatory processes by histone deacetylase inhibitors [Elektronische Ressource] / von Stephanie Spange

Modulation of posttranscriptional and posttranslational regulatory processes by histone deacetylase inhibitors Dissertation Zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) vorgelegt dem Rat der biologisch-Pharmazeutischen Fakultät der Friedrich-Schiller Universität Jena von Diplombiochemikerin Stephanie Spange geboren am 12. 07. 1981 in Erfurt, Deutschland “Success is going from failure to failure without a loss of enthusiasm.” Winston Churchill Index 0 I Acetylation as an important cell signalling modulator 1. SUMMARY ....................................................................................................................................... 1 2. ZUSAMMENFASSUNG ...................................................................................................................... 2 3. INTRODUCTION ................................................................................................................................... 3 3.1. ACETYLATION AS AN IMPORTANT POSTTRANSLATIONAL MODIFICATION ........................... 3 3.1.1 Protein acetylases and –deacetylases ..................................................................................... 6 3.1.2 Protein deacetylases as chemotherapeutic targets ................................. 7 3.2 SIRT1......................................................................