Modelling and treating Huntington's disease [Elektronische Ressource] : generation of high-capacity adenovirus vectors to express normal and mutant huntingtin and to block huntingtin expression by short hairpin interference RNA / vorgelegt von Huang Bin

Modelling and treating Huntington’s disease: Generation of high-capacity adenovirus vectors to express normal and mutant huntingtin and to block huntingtin expression by short hairpin interference RNA Dissertation zur Erlangung des Doktorgrades Dr. rer. nat der Fakultät für Naturwissenschaften der Universität Ulm vorgelegt von Huang Bin, aus China 2007 Amtierender Dekan: Professor Dr. Klaus-Dieter Spindler Erstgutacher: Professor Dr. Klaus-Dieter Spindler Zweitgutacher: Professor Dr. Thomas Wirth Date of oral examination: 18.02.2008 1 Index I. Abstract .....................................................................................................................4 II. Papers in this thesis.................................................................................................6 III. Abbreviations.........................................................................................................7 IV. Introduction ...........................................................................................................8 IV.1 Overview of HD...................................................................................................9 IV.1.1 Clinical features..........................................................................................9 IV.1.2 Pathology ..................................................................