Modeling of cardiac uptake, binding kinetics and inotropic response of amidarone, verapamil and {α_tn1-adrenergic [alpha 1-adrenergic] agents in isolated perfused rat heart [Elektronische Ressource] / von Pakawadee Sermsappasuk

Modeling of Cardiac Uptake, Binding Kinetics and Inotropic Response of Amiodarone, Verapamil and a -Adrenergic Agents in Isolated Perfused Rat Heart 1 D i s s e r t a t i o n zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat) vorgelegt der Naturwissenschaftlichen Fakultät I Biowissenschaften der Martin-Luther-Universität Halle-Wittenberg von Frau Pakawadee Sermsappasuk geb. am 24.01.1976 in Bangkok, Thailand Gutachter: 1. Prof. Dr. Michael Weiss 2. Prof. Dr. Reinhard Neubert 3. PD Dr. Willi Weber Halle (Saale), 19. Dezember 2007urn:nbn:de:gbv:3-000012862[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000012862] Table of Contents 1. Introduction ................................................................................................. 1 1.1. Pharmacokinetic/ Pharmacodynamic Modeling Concept................................ 1 1.2. Cardiophysiology........................................................................................... 3 2. Langendorff Heart....................................................................................... 7 2.1. Principle ........................................................................................................ 7 2.2. Langendorff Isolated Perfused Rat Heart System ........................................... 9 2.3. Langendorff Isolated Perfused Heart Preparation ......................................... 11 3.