Mitogenic signaling by G_1tnq_1tn/_1tn1_1tn1-coupled receptors [Elektronische Ressource] / by Susanne Roelle

Introduction For my parents Mathilde and Wolfgang For my sister Barbara 1 Introduction From the Institute of Pharmacology and Toxicology Philipps-University Marburg Director: Prof. Dr. med. Thomas Gudermann Mitogenic signaling by G -coupled receptors q/11 Inaugural dissertation to obtain a degree of a doctor in natural sciences (Dr. rer. nat.) presented to the Department of Chemistry Philipps-University Marburg by Susanne Roelle born in Brühl/Rheinland 2 Introduction Accepted by the Department of Chemistry on April 7, 2004 st1 referee: Prof. Dr. Thomas Carell nd2 referee: Prof. Dr. Thomas Gudermann Day of oral examination: April 15, 2004 3 Introduction TABLE OF CONTENTS 1. Introduction ................................................................................................ 12 1.1. Signaling pathways emanating from G protein-coupled receptors (GPCRs)12 1.2. Mitogenic signaling by G -coupled receptors............................................ 15 q/112+1.2.1. Ca -mediated activation of Pyk2................................................................. 19 1.2.2. GPCR-dependent Epidermal Growth Factor receptor transactivation ......... 20 1.3. Neuropeptide-mediated ERK activation....................................................... 24 1.3.1.