Misclassification in genetic variants and its impact on genetic association studies [Elektronische Ressource] / by Claudia Lamina

From the Institute of Medical Information Processing, Biometry, and Epidemiology of the University of Munich, Germany Chair of Epidemiology: Prof. Dr. med. Dr. rer. nat. H.-Erich Wichmann and the Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH) Director: Prof. Dr. med. Dr. rer. nat. H.-Erich Wichmann Misclassification in genetic variants and its impact on genetic association studies Thesis Submitted for a Doctoral degree in Human Biology at the Faculty of Medicine Ludwig-Maximilians-University, Munich, Germany by Claudia Lamina from Augsburg, Germany 2009 With approval of the Medical Faculty of the University of Munich First reviewer: Prof. Dr. med. Dr. rer. nat. H.-Erich Wichmann Second reviewer: Priv. Doz. Dr. Roland Kappler Priv. Doz. Dr. Rudolf A. Jörres Co-supervision: Dr. rer. biol. hum. Iris Heid Dean: Prof. Dr. med. Dr. h.c. M. Reiser, FACR, FRCR Date of the oral examination: 28.04.2009 Acknowledgment First of all, I would like to thank Prof. Dr. Dr. H.-Erich Wichmann, for the opportunity to work on this interesting and varied topic and for the constant support. I am grateful for the inspiring working environment at the Institute of Epidemiology and the manifold chances to present this work at national and international conferences. I would like to thank Dr.