Sarazin Etude diagnostique

AmnesticsyndromeofthemedialtemporaltypeidentifiesprodromalADAlongitudinalstudyM.Sarazin,PhD* ABSTRACTC.Berr,PhD* Objective:Tocomparethepoweroftestsassessingdifferentcognitivedomainsfortheidentifica-J.DeRotrou,PhD tion of prodromal Alzheimer disease (AD) among patients with mild cognitive impairment (MCI).C.Fabrigoule,PhDBackground: Given the early involvement of the medial temporal lobe, a precocious and specificF.Pasquier,PhDpattern of memory disorders might be expected for the identification of prodromal AD.S.Legrain,MDMethods: A total of 251 patients with MCI were tested at baseline by a standardized neuropsy-B.Michel,MDchologicalbattery,whichincludedtheFreeandCuedSelectiveRecallRemindingTest(FCSRT)forM.Puel,MDverbal episodic memory; the Benton Visual Retention Test for visual memory; the Deno 100 andM.Volteau,PhDfluencyforlanguage;aserialdigitlearningtestandthedoubletaskofBaddeleyforworkingJ.Touchon,MDmemory;WechslerAdultIntelligenceScale(WAIS)similaritiesforconceptualelaboration;andtheM.Verny,PhDStroop test, the Trail Making test, and the WAIS digit symbol test for executive functions. TheB.Dubois,MDpatients were followed at 6-month intervals for up to 3 years in order to identify those whoconverted to AD vs those who remained stable over time. Statistical analyses were based onAddresscorrespondenceand receiver operating characteristic curve and Cox proportional hazards models.reprintrequeststoDr.MarieSarazin,INSERMU610and Results ...