16-Audit-Weiss

The Scientific Data Verification and Auditing System of theCancer and Leukemia Group B(CALGB)Raymond B. Weiss, M.D.Chair, CALGB Data Audit CommitteeCALGB CRA Orientation, November 2006Why Do Audits?1Stem-cell Transplant for Breast Cancer• Bezwoda WR, et al: High-dose chemotherapy with hematopoietic rescue as primary treatment for metastatic breast cancer: A randomized trial. J Clin Oncol1995;13:2483-9.“[High-dose chemotherapy] …results in a significant proportion of CRs and increased survival in patients with metastatic breast cancer.”• Weiss RB, et al: An on-site audit of the South African trial of high-dose chemotherapy for metastatic breast cancer and associated publications. J Clin Oncol 2001;19:2771-7.“The multiple publications of this study do not report verifiable data, and 9 other publications coauthored by the PI contain at least one major untrue statement.”Cancer researcher admits falsifyingtrial resultsTrial results presented at ASCO's annual meetingmisrepresented treatment in the control group.JOHANNESBURG--- The University of Witwatersrand Medical School is investigating Werner Bezwoda,MD, PhD, for scientific misconduct for allegedly lying about the results of a clinical trial on high-dosechemotherapy and stem cell support for breast cancer. In a document recently sent to his colleagues,Bezwoda acknowledged that he 'committed a serious breach of scientific honesty and integrity" bymisrepresenting the results of that trial ...