Mechanisms of β-cell [beta-cell] loss in male Munich Ins2_1hnC_1hn9_1hn5_1hnS mutant mice [Elektronische Ressource] / by Sabine Martha Kautz

From the Institute of Veterinary Pathology Department of General Pathology and Pathological Anatomy Chair: Prof. Dr. W. Hermanns Ludwig-Maximilians-Universität München Under the supervision of Dr. N. Herbach and Prof. Dr. R. Wanke Mechanisms of β-cell loss C95Sin male Munich Ins2 mutant mice Inaugural-Dissertation to achieve the doctor title of veterinary medicine at the Faculty of Veterinary Medicine of the Ludwig-Maximilians-Universität, Munich by Sabine Martha Kautz from Schwanstetten Munich 2010 Gedruckt mit der Genehmigung der Tierärztlichen Fakultät der Ludwig-Maximilians-Universität München Dekan: Univ.-Prof. Dr. Braun Berichterstatter Univ.-Prof. Dr. Wanke Korreferent/en: Univ.-Prof. Dr. Gabius Univ.-Prof. Aigner Prof. Dr. Kaltner Dr. Ammer Tag der Promotion: 13. Februar 2010 Für meine Eltern und meinen Freund Lothar Table of content 1 Introduction 1 2 Literature review 3 2.1 Diabetes mellitus 3 2.1.1 Prevalence 3 2.1.2 Costs 3 2.1.3 Definition, description, classification and diagnosis of diabetes mellitus 4 2.1.3.1 Definition and description 4 2.1.3.2 Classification 5 2.1.3.3 Diagnosis 7 2.2 Types of diabetes mellitus 8 2.2.1 Diabetes type 1 8 2.2.2 Diabetes type 2 9 2.2.3 Monogenic forms of diabetes mellitus 10 2.2.3.1 Maturity-onset diabetes of the young (MODY) 10 2.2.3.2 Neonatal diabetes mellitus (NDM) 11 2.