Mechanism and control of nuclear cytoplasmic translocation of the transporter regulator RS1 [Elektronische Ressource] = Mechanismus und Kontrolle der Translokation der Transporterregulator RS1 zwischen Kern und Zytoplasma / submitted by Alina Filatova

Mechanism and Control of Nuclear-Cytoplasmic Translocation of the Transporter Regulator RS1 Mechanismus und Kontrolle der Translokation der Transporterregulator RS1 zwischen Kern und Zytoplasma Doctoral thesis for a doctoral degree at the Graduate School of Life Sciences, Julius-Maximilians-Universität Würzburg, Section Biomedicine submitted by Alina Filatova from Khimki, Russia Würzburg, 2009 Submitted on: …………………………………………………………..…………… Office stamp Members of the Promotionskomitee: Chairperson: …….………Prof. Dr. Thomas Hünig……………...... Primary Supervisor: ……Prof. Dr. Hermann Koepsell…..……… Supervisor (Second): ……Prof. Dr. Roland Benz.….…………...... Supervisor (Third): ……...Dr. Heike Hermanns………….....…..... Date of Public Defence: …………………………………………….. Date of receipt of Certificates: ……………………………………... Table of contents . Table of contents 1. INTRODUCTION ........................................................................................................ 1 1.1. The RS1 protein ...................................................................................................... 1 1.2. Transport of proteins in and out of the nucleus................................................... 5 1.2.1. Nuclear protein import pathways ................................