Mass spectrometric characterization of elastin peptides and the effect of solar radiation on elastin [Elektronische Ressource] / von Melkamu Getie Kebtie

MASS SPECTROMETRIC CHARACTERIZATION OF ELASTIN PEPTIDES AND THE EFFECT OF SOLAR RADIATION ON ELASTIN Dissertation zur Erlangung des akademischen Grades Doktor rerum naturalium (Dr. rer. nat.) vorgelegt der Mathematisch-Naturwissenschaftlich-Technischen Fakultät (mathematisch-naturwissenschaftlicher Bereich) der Martin-Luther-Universität Halle-Wittenberg von Melkamu Getie Kebtie geboren am 02.10.1972 in Gundewoin, Äthiopien Gutachter: 1. Prof. Dr. Dr. Reinhard Neubert 2. Prof. Dr. Michael Linscheid 3. PD Dr. Johannes Wohlrab Halle (Saale), den 08. Dezember 2005urn:nbn:de:gbv:3-000009457[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000009457]Dedication This work is dedicated to my brother the late Dr. Anteneh Getie and my sister the late Ayalnesh Getie IITable of contents TABLE OF CONTENTS 1. INTRODUCTION................................................................................................................1 2. BACKGROUND ..................................................................................................................4 2.1. Elastic fibers .................................................................................................................4 2.1.1. Composition, structure and distribution .................................................................4 2.1.2. Biosynthesis of elastic fibers........................................