Management of pregnancies with gestational diabetes based solely on maternal glycemia versus glycemia plus fetal growth [Elektronische Ressource] / vorgelegt von Ute M. Schäfer-Graf

Klinik für Geburtsmedizin, Universitätsmedizin Berlin, Campus Virchow-Klinikum HABILITATIONSSCHRIFT Management of pregnancies with gestational diabetes based solely on maternal glycemia versus glycemia plus fetal growth Zur Erlangung der venia legendi der Medizinischen Fakultät Charité der Humboldt-Universität zu Berlin vorgelegt von Dr. Ute M. Schäfer-Graf Berlin, Mai 2003 Öffentlich-wissenschaftlicher Vortrag: 19. Februar 2004 Gutachter: 1. Prof. Dr. Grab, München 2. PD Dr. Beinder, Zürich Content 2 Content 1. Introduction 4 1.1 Intention of the presented work 4 1.2 Gestational Diabetes 6 1.2.1 Epidemiology and pathophysiology 6 1.2.2 Maternal and neonatal morbidity 6 1.2.3. Diagnostic management 7 1.2.4. Therapy 9 2. Own contributions 10 2.1 The influence of maternal glycemic values on embryogenesis 10 2.1.1 Introduction and summary 10 • Congenital malformations in offspring of women with gestational diabetes 11 • Patterns of congenital anomalies and relationship to initial maternal hyperglycemia 12 2.1.2 Discussion 12 2.2. The influence of maternal glycemic values on fetal growth and neonatal morbidity 15 2.2.1 Studies in pregnancies with borderline glucose intolerance 15 2.2.1.