Lysine-specific histone demethylase 1 (LSD1): a novel molecular target for tumor therapy [Elektronische Ressource] / submitted by Soyoung Lim

Lysinespecific histone demethylase 1 (LSD1): A novel molecular target for tumor therapy Thesis Submitted for a Doctoral Degree in Natural Sciences (Dr. rer.nat.) Mathematics and Natural Sciences Faculty Rheinische Friedrich Wilhelms University, Bonn Submitted by Soyoung Lim from South Korea Bonn, 2009 Angefertigt mit Genehmigung der MathematischNaturwissenschaftlichen Fakultät der Rheinischen FriedrichWilhelmsUniversität Bonn Supervisor: Prof. Dr. Reinhard Büttner First reviewer: Prof. Dr. Christa E. Müller Second reviewer: Prof. Dr. Evi Kostenis Third reviewer: Prof. Dr. Hubert Schorle Date of Submission: 14. Jul. 2009 Date of Examination: 12. Nov. 2009 Declaration I solemnly declare that the work submitted here is the result of my own investigation, except where otherwise stated. This work has not been submitted to any other university or institute towards the partial fulfillment of any degree. Soyoung Lim Table of contents Table of contents Table of contents..............................................................................................................i Summary........................................................................................................................vi Abbreviations........................................................