Low chloride conductance myotonia [Elektronische Ressource] : in vitro investigations on muscle stiffness and the warm-up phenomenon / submitted by Sunisa Chaiklieng

Ulm University Institute of Applied Physiology Prof. Dr. Dr. h.c. Frank Lehmann-Horn Low chloride conductance myotonia - in vitro investigations on muscle stiffness and the warm-up phenomenon Dissertation Applying for the Degree of Doctor of human biology (Dr. biol. hum.) Faculty of Medicine, Ulm University Submitted by Sunisa Chaiklieng From Phatthalung, Thailand 2007 Amtierender Dekan: Prof. Dr. Klaus-Michael Debatin 1. Berichterstatter: Prof. Dr. Dr. h.c. Frank Lehmann-Horn 2. Berichterstatter: Prof. Dr. Holger Lerche Tag der Promotion: 18.12.2007 I TABLE OF CONTENTS ABBREVIATIONS 1 INTRODUCTION 1 1.1 MYOTONIA - HYPEREXCITABILITY OF SKELETAL MUSCLE.......................................1.2 LOW CHLORIDE CONDUCTANCE MYOTONIA ............................................................ 1 1.2.1 THOMSEN’S AND BECKER’S MYOTONIA ................................................................... 1 1.2.2 PATHOPHYSIOLOGICAL BACKGROUND ..................................................................... 3 1.2.3 WARM-UP PHENOMENON.......................................................................................... 3 1.3 PHYSIOLOGICAL AND MICROENVIRONMENTAL MODIFYING FACTORS ..................... 4 1.4 GENETICS ...............................................................................