Lineage commitment of conditionally immortalized bone marrow mesenchymal stromal cells from tetracycline-regulated SV40 large T-antigen transgenic mice [Elektronische Ressource] / Maria Rostovskaya

DRESDEN UNIVERSITY OF TECHNOLOGY FACULTY OF MATHEMATICS AND NATURAL SCIENCES LINEAGE COMMITMENT OF CONDITIONALLY IMMORTALIZED BONE MARROW MESENCHYMAL STROMAL CELLS FROM TETRACYCLINE-REGULATED SV40 LARGE T-ANTIGEN TRANSGENIC MICE PHD THESIS MARIA ROSTOVSKAYA Dresden, July 2010 INTERNATIONAL MAX PLANCK RESEARCH SCHOOL MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS LINEAGE COMMITMENT OF CONDITIONALLY IMMORTALIZED BONE MARROW MESENCHYMAL STROMAL CELLS FROM TETRACYCLINE-REGULATED SV40 LARGE T-ANTIGEN TRANSGENIC MICE D I S S E R T A T I O N zur Erlangung des akademischen Grades Doctor rerum naturalium (Dr. rer. nat.) vorgelegt der Fakultät Mathematik und Naturwissenschaften der Technischen Universität Dresden von ROSTOVSKAYA MARIA geboren am 22.04.1981 in Ramenskoe, Russia Gutachter: Prof. Dr. Francis Stewart Prof. Dr. Austin Smith Eingereicht am: 6. July, 2010 Tag der Verteidigung: 30. November, 2010 2 
Abstract Adult bone marrow contains a population of mesenchymal stem cells capable to self-renew and to differentiate into haematopoietic-supportive stroma, osteo, adipo- and chondrocytes. However, the identity of mesenchymal stem cells still remains uncertain.