Leukemia inhibitory factor enhances neurogenin's pro-neural effect during mouse cortical development [Elektronische Ressource] / von Sascha Hasan

Leukemia inhibitory factor enhances neurogenin´s pro-neural effect during mouse cortical development Dissertation zur Erlangung des Doktorgrades der Naturwissenschaften vorgelegt beim Fachbereich Biologie und Informatik der Johann Wolfgang Goethe-Universitaet in Frankfurt am Main, Deutschland von Sascha Hasan aus Heidelberg, Deutschland Frankfurt am Main 2007 2 Vom Fachbereich Biologie und Informatik der Johann Wolfgang Goethe-Universitaet als Dissertation angenommen Dekan: Prof. Dr. R. Wittig Gutachter: Prof. Dr. W. Volknandt Prof. Dr. Y. Sun Datum der Disputation: 3Table of contents 1 Introduction...............................................................................................6 1.1 Neural stem cells and cortical development ..............................................7 1.2 Intrinsic factors that promote cortical neurogenesis: proneural basic helix- loop-helix transcription factors.................................................................10 1.3 Extrinsic factors that regulate cortical development.................................15 1.4 Mechanisms by which neurogenin inhibits gliogenesis and promotes neurogenesis..............................................................................................16 1.