Kruppel-like factor 4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classical Hodgkin lymphoma [Elektronische Ressource] / presented by Hanfeng Guan

Universität Ulm Institut fuer Physiologische Chemie Direktor: Prof. Thomas Wirth Kruppel-like factor 4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classical Hodgkin lymphoma Dissertation for the attainment of the Doctoral Degree of Medicine (Dr. med.) at the Faculty of Medicine, University of Ulm, Ulm, Germany Presented by Hanfeng Guan born in Zaoyang, Hubei Province, P. R. China 2011 Amtierender Dekan: Prof. Dr. rer. Nat Thomas Wirth 1. Berichterstatter: Prof. Dr. rer. Nat Thomas Wirth 2. Berichterstatter: Prof. Dr. Peter Möller Tag der Promotion: 14.01.2011 - II - Contents Abbreviations....................................................................................................................... IV  1 Introduction........................ 1  1.1 B-cell lymphoma ......................................................................................................... 1  1.1.1 Classical Hodgkin Lymphoma............. 3  1.1.2 Hodgkin and Reed-Sternberg cells....... 3  1.1.3 Burkitt's lymphoma (BL)...................................................................................... 5  1.2 Epigenetic mechanisms in cHL lymphogenesis.......................... 5  1.3 Krüppel-like factor 4................................... 6  1.4 Aims of the Study.......................................