Isolation and characterization of bacteria from the deep sea and their potential to produce bioactive natural products [Elektronische Ressource] / vorgelegt von Andrea Gärtner

Isolation and characterization of bacteria from the deep sea and their potential to produce bioactive natural products Dissertation zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultät der Christian-Albrechts-Universität zu Kiel Vorgelegt von Andrea Gärtner Kiel 2011 Referent: Prof. Dr. Johannes F. Imhoff Korreferent: Prof. Dr. Peter Schönheit Tag der mündlichen Prüfung: 25.03.2011 Zum Druck genehmigt: 25.03.2011 gez. Prof. Dr. Lutz Kipp, Dekan Table of Contents Summary 4Zusammenfassung 5Introduction 1. Prokaryotic life in the deep sea 8 1.1. Microbial life in the oligotrophic deep sea 12 1.1.1.The Eastern Mediterranean Sea 13 1.2.Microbial life at deep-sea hydrothermal vent fields 15 1.2.1.The Logatchev hydrothermal vent field (LHF) 16 2. The deep sea as a treasure crest for new natural products 18 3. Aims of the thesis 23 4. Thesis outline 25 Chapters Chapter I: Isolation and characterization of bacteria from the Eastern 28 Mediterranean deep sea Chapter II: Micromonospora strains from the Mediterranean deep sea as 48 promising sources for new natural products Chapter III: Levantilide A and B, novel macrolides isolated from the 67 deep-sea Micromonospora sp.