Isoform-specific loss of CD44 interferes with different aspects of the metastatic process [Elektronische Ressource] / presented by Pamela Klingbeil

Dissertation submitted to the Combined Faculties for the Natural Sciences and for Mathematics of the Ruperto-Carola University of Heidelberg, Germany for the degree of Doctor of Natural Sciences presented by Dipl. Biol. Pamela Klingbeil born in Berlin Oral-examination: Isoform-specific Loss of CD44 Interferes with Different Aspects of the Metastatic Process Referees: PD Dr. Jochen Wittbrodt Prof. Dr. Margot Zöller Whenever you fall, pick something up. Oswald Theodore Avery Table of Contents Table of Contents Summary.................................................................................................................................. 1 Zusammenfassung.................................................................................................................... 2 1. Introduction.................................................................................................................. 4 1.1 Cancer evolves as a multistep process.................................................................................. 4 1.2 The BSp73 cell system......................................................................................................... 12 1.3 The cell-cell and cell-matrix adhesion molecule CD44.......................................