Iron labeling of mesenchymal stem, stromal cells for magnetic resonance imaging [Elektronische Ressource] : studies on poly-L-lactic acid-iron nanoparticles / presented by Gerlinde Schmidtke-Schrezenmeier

From the Clinic of Dermatology and Allergology of the University Hospital Ulm Head: Prof. Dr.med. Karin Scharffetter-Kochanek Iron Labeling of Mesenchymal Stem/Stromal Cells for Magnetic Resonance Imaging: Studies on Poly-L-Lactic Acid – Iron Nanoparticles Dissertation Submitted to the Medical Faculty of the University of Ulm for the degree of Doctor of Medicine Presented by Gerlinde Schmidtke-Schrezenmeier, born in Altheim/Alb, Germany 2009 Dean of the Faculty of Medicine: Prof. Dr. med. Klaus-Michael Debatin 1st Reviewer: Prof. Dr. med. Karin Scharffetter-Kochanek 2nd Reviewer: Prof. Dr. rer.nat. Katharina Landfester Day of grant of Doctorate: November 6, 2009 ii Just for me – it is never too late! With deep love and gratitude to my husband. Also thanks to the other usual suspects, my kids and dogs. iii List of Content Abbreviations vi 1. Introduction ..................................................................................................... 1 1.1. Mesenchymal stem/stromal cells .............................. 1 1.2. Magnetic resonance imaging .... 1 1.3. Magnetic resonance imaging contrast agents ........................................... 3 1.4. Iron loaded poly-L-lactide nanoparticles .................... 5 1.5. Scope of the dissertation ........................................... 7 2. Materials and methods ..........