Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases [Elektronische Ressource] / vorgelegt von Anna Papazoglou

INVOLVEMENT OF THE LYSOSOMAL CYSTEINE PEPTIDASE CATHEPSIN B IN PEPTIDASE CATHEPSIN B IN TUMOUR PROGRESSION AND FORMATION OF METASTASES Inauguraldissertation zur Erlangung der Doktorwürde der Fakultät für Biologie der Albert-Ludwigs-Universität, Freiburg i. Br., Deutschland Vorgelegt von Anna Papazoglou aus Athen, Griechenland November 2003 Die vorliegende Arbeit entstand im Institut für Molekulare Medizin und Zellforschung der Albert-Ludwigs-Universität, Freiburg i. Br., Deutschland, unter der Anleitung von Prof. Dr. C. Peters. Dekan: …………………………………….. Promotionsvorsitzender: Betreuer der Arbeit: Prof. Dr. Christoph Peters Weiterer Betreuer: …………………………………….. Referent: Prof. Dr. Christoph Peters Ko-Referent: Prof. Neubüser ii I will lift my eyes to the hills wher my help comes from? My help comes from the LORD, who made heaven and earth. Psalm 121;1-2 iii ACKNOWLEDGMENTS I am telling everyone that this thesis was, entirely, the product of my own hard labour, but this is not really true. Throughout this work several people have offered their contribution and they did so in many different ways. So, to all those who have helped, I want to express my most sincere thanks. However, some people deserve a special mention.