Investigation of protein expression dynamics in human tumor cells following pharmacological treatment [Elektronische Ressource] = Untersuchungen zur Proteinexpressionsdynamik in humanen Tumorzellen nach pharmakologischer Behandlung / Sven Nahnsen

Investigation of protein expression dynamics inhuman tumor cells following pharmacologicaltreatmentInsights from wet and dry lab approachesDissertationder Mathematisch-Naturwissenschaftlichen Fakult atder Eberhard Karls Universit at Tubingenzur Erlangung des Grades einesDoktors der Naturwissenschaften(Dr. rer. nat.)vorgelegt vonDipl.-Biotech. Sven Nahnsenaus Heilbronn-NeckargartachTubingen2010Tag der mundlic hen Quali kation: 20/12/2010Dekan: Prof. Dr. Wolfgang Rosenstiel1. Berichterstatter: Prof. Dr.-Ing. Oliver Kohlbacher2. Berich Prof. Dr. Alfred NordheimThis thesis is dedicated to the memory of Andreas Bertsch, my dearfriend, whom I thank for a great time together. Andreastaught me C++ and instilled endless enthusiasm forthe eld of computational proteomics.AcknowledgementsI would like to express my deepest gratitude to my advisors OliverKohlbacher and Alfred Nordheim. They gave me the opportunity toundertake this interdisciplinary PhD project. They encouraged andsupported me at any time during my graduate studies; their open-mindedness gave me the con dence to pursue this direction.I am also very grateful to Boris Macek for sharing his enormous knowl-edge in mass spectrometry and the great scienti c support.