Investigating the molecular basis for the constitutive activity of the nuclear hormone receptor CAR [Elektronische Ressource] / von Björn Anselm Windshügel

Investigating the Molecular Basis for theConstitutive Activity of the NuclearHormone Receptor CARDissertationzur Erlangung des akademischen Gradesdoctor rerum naturalium (Dr. rer. nat.)vorgelegt derMathematisch Naturwissenschaftlich Technischen Fakult at¨(mathematisch naturwissenschaftlicher Bereich)der Martin Luther Universit at¨ Halle Wittenbergvon Herrn Bjorn Anselm Windshugel¨ ¨geb. am 1. Januar 1976 in Bietigheim BissingenGutachter:1. Prof. Dr. Wolfgang Sippl2. PD Dr. Wolfgang Brandt3. Prof. Dr. Antti PosoHalle (Saale), den 19. Juli 2006urn:nbn:de:gbv:3-000010669[http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000010669]AcknowledgementsThe present work was carried out at the Institute of Pharmaceutical Chemistry ofthe Heinrich Heine University Dusseldorf¨ from 2002 to 2003 and at the Instituteof Pharmaceutical Chemistry of the Martin Luther University Halle Wittenbergfrom 2003 to 2006. In summer 2003 and 2004 I had the great opportunity to stayat the and Medicinal Chemistry (PMC) group of Prof. Dr. AnttiPoso at the University of Kuopio, Finland.First of all, I’d like to thank my supervisor Prof. Dr. Wolfgang Sippl for givingme the opportunity to join his group and to get in touch with the fascinatingworld of nuclear receptors. I’d like to thank him for the support and the possi bility for a stay abroad during my work.The support by Dr. Paavo Honkakoski and his group is greatly acknowl edged.