Introduction for EPA Benchmark Dose Online Training Session

Introduction

Slide 1:
Welcome to the EPA Benchmark Dose Online Training Session. This training session is
designed to provide risk assessors with guidance on how to use benchmark dose
modeling in dose response analysis.

Slide 2:
The complete training session consists of five modules. This introduction is the first of
the five benchmark dose training modules. The second module will cover dichotomous
modeling, the third module will cover cancer modeling, the fourth continuous modeling,
and the fifth the nested modeling. In this introduction module, we will present
background on the benchmark dose method, and the advantages and limitations of using
this method in chemical risk assessment.

Slide 3:
The introduction module includes four sections. They are: Background for the
benchmark dose (or BMD) approach, Definition of BMD, Pros and Cons for BMD, as
well as General procedures in BMD modeling. First, we are going to provide some
background for the benchmark dose approach.

Slide 4:
Dose response assessment, including dose-response modeling, has long been recognized
as a key component of the chemical risk assessment paradigm as is illustrated in this
diagram from the 1983 National Academy of Science’s report on risk assessment.


Slide 5:
As was shown in the previous NAS diagram, risk assessment is composed of 4 major
components:
The Hazard Identification or Characterization, which covers what kind of effects one
might expect after ...