Integrin-mediated interactions between cells and biomimetic materials [Elektronische Ressource] / presented by Robert Knerr

Integrin-mediated Interactions between Cells and Biomimetic Materials Integrin-mediated Interactions between Cells and Biomimetic Materials Dissertation to obtain the Degree of Doctor of Natural Sciences (Dr. rer. nat.) from the Faculty of Chemistry and Pharmacy University of Regensburg Presented by Robert Knerr from Hemau November 2006 This work was carried out from July 2002 until June 2006 at the Department of Pharmaceutical Technology of the University of Regensburg. The thesis was prepared under supervision of Prof. Dr. Achim Göpferich. Submission of the PhD. application: 20.11.2006 Date of examination: 13.12.2006 Examination board: Chairman: Prof. Dr. Heilmann 1. Expert: Prof. Dr. Göpferich 2. Expert: Prof. Dr. Ruhl 3. Examiner: Prof. Dr. Franz To my family and Beate ‚Die Wissenschaft von heute ist der Irrtum von morgen.’ Jakob von Üxküll Integrin-mediated Interactions between Cells and Biomimetic Materials Table of Contents Chapter 1 Introduction and Goals of the Thesis..........................................7 Chapter 2 Synthesis and Characterization of Self-assembling Thioalkylated PEG Derivatives..................................................49 Chapter 3 Self-assembling PEG Derivatives for Protein-repellant Biomimetic Model Surfaces ......................