Insights into the clonal inventory of gene corrected human SCID-X1 hematopoiesis [Elektronische Ressource] / vorgelegt von Jingqiong Hu

Aus dem Institut für Molekulare Medizin und Zellforschung der Albert-Ludwigs-Universität Freiburg i. Br. INSIGHTS INTO THE CLONAL INVENTORY OF GENE CORRECTED HUMAN SCID-X1 HEMATOPOIESIS INAUGURAL-DISSERTATION zur Erlangung des Medizinischen Doktorgrades der Medizinischen Fakultät der Albert-Ludwigs-Universität Freiburg i. Br. vorgelegt 2004 von Jingqiong Hu geboren in Shanghai, V.R.China Dekan: Prof. Josef Zentner Erster Gutachter: Prof. Christof von Kalle Zweiter Gutachter: Prof. Fritz von Weizsäcker Jahr der Promotion: 2004 DECLARATION I hereby do solemnly declare that: the work presented in this dissertation has been carried out by me, under the supervision of Professor Christof von Kalle of the Molecular and Gene Therapy Programme Group, Division of Experimental Hematology, Cincinnati Children’s Hospital in USA and Dr. Manfred Schmidt of the Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University of Freiburg in Germany. Signed Name: Jingqiong Hu Table of Contents - I - TABLE OF CONTENTS 1 INTRODUCTION............................................................................1 1.1 Hematopoiesis and Hematopoietic Stem Cells....